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In clinical trials, a higher percentage of QSYMIA-treated adults and pediatric patients aged 12 years and older experienced heart rate increases from baseline of more than 5, 10, 15, and 20 bpm compared to placebo-treated patients

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The original FLOW (Evaluate Renal Function with Semaglutide Once Weekly) trial in 3533 patients with type 2 diabetes and CKD found subcutaneous semaglutide 1 mg once weekly reduced the risk of the primary kidney endpoint (at least a 50% decline of estimated glomerular filtration rate, kidney failure or kidney or cardiovascular death) by 24% and all-cause death by 20%

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